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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
AFF2
All Species:
16.06
Human Site:
S486
Identified Species:
50.48
UniProt:
P51816
Number Species:
7
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P51816
NP_002016.2
1311
144771
S486
Q
A
S
G
G
S
G
S
S
S
E
S
E
S
S
Chimpanzee
Pan troglodytes
Q7YQM2
1272
140491
T478
N
E
A
P
R
V
A
T
P
E
P
E
P
P
S
Rhesus Macaque
Macaca mulatta
XP_001088220
1311
144821
S486
Q
T
S
G
G
S
G
S
S
S
E
S
E
S
S
Dog
Lupus familis
XP_549313
1547
169935
S712
R
T
S
G
A
S
G
S
S
S
D
S
E
S
S
Cat
Felis silvestris
Mouse
Mus musculus
O55112
1272
140163
T482
N
E
A
P
R
V
A
T
P
E
P
E
P
P
S
Rat
Rattus norvegicus
XP_219832
1355
148400
S525
Q
A
S
V
G
S
G
S
S
S
E
S
E
S
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507403
1221
131271
S449
P
P
G
G
G
V
S
S
D
S
G
S
S
S
D
Chicken
Gallus gallus
XP_001233772
1353
145477
G512
L
S
A
I
H
T
P
G
K
A
E
Q
S
K
F
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
96.4
98.1
71.2
N.A.
86.3
84.3
N.A.
32.6
23.4
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
96.7
99
75.1
N.A.
90.5
88.7
N.A.
48.9
40.7
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
6.6
93.3
73.3
N.A.
6.6
93.3
N.A.
40
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
20
93.3
86.6
N.A.
20
93.3
N.A.
40
33.3
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
25
38
0
13
0
25
0
0
13
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
13
0
13
0
0
0
13
% D
% Glu:
0
25
0
0
0
0
0
0
0
25
50
25
50
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
13
% F
% Gly:
0
0
13
50
50
0
50
13
0
0
13
0
0
0
0
% G
% His:
0
0
0
0
13
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
13
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
13
0
0
0
0
13
0
% K
% Leu:
13
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
25
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
13
13
0
25
0
0
13
0
25
0
25
0
25
25
0
% P
% Gln:
38
0
0
0
0
0
0
0
0
0
0
13
0
0
0
% Q
% Arg:
13
0
0
0
25
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
13
50
0
0
50
13
63
50
63
0
63
25
63
75
% S
% Thr:
0
25
0
0
0
13
0
25
0
0
0
0
0
0
0
% T
% Val:
0
0
0
13
0
38
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _